CoMFA – MFer. March 8, 2007Posted by thwalls in Blogroll.
So I’m finishing up some of my work and of course a CoMFA is required since my work centers around the inhibition of a particular transmembrane protein. Of course, if you’re familiar with medicinal chemistry, you’ll know that every medchem student is entrenched with the thorough understanding that if the computer tells you the analog is good, then obviously…it’s good. This then leads to your PI telling you to make all 150,000 analogs that could possibly be good since, hey, the in vitro data may be different.
I hate Sybyl, and I think it equally hates me.
And possibly you too.